2. Signaling Pathways
  3. Anti-infection
  4. Reverse Transcriptase

Reverse Transcriptase

Reverse Transcriptase

Related Products

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Reverse transcriptases (RTs) are enzyme used to generate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription. Reverse transcriptases (RTs) use an RNA template and a short primer complementary to the 3' end of the RNA to direct the synthesis of the first strand cDNA.

Nucleoside reverse transcriptase inhibitors (NRTIs) block reverse transcriptase (an HIV enzyme). Non-nucleoside reverse transcriptase inhibitors (NNRTIs) bind to and block HIV reverse transcriptase. HIV uses reverse transcriptase to convert its RNA into DNA (reverse transcription). Blocking reverse transcriptase and reverse transcription prevents HIV from replicating.

Reverse Transcriptase Related Products (259):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-10570S
    Nevirapine-d4
    		Inhibitor
    Nevirapine-d4 is deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a Ki of 270 μM.
    Nevirapine-d<sub>4</sub>
  • HY-W320523
    ALizarin complexone dihydrate
    		Inhibitor
    ALizarin complexone dihydrate is the dehydrate of Alizarin complexone (HY-121075). Alizarin complexone is a calcium-binding fluorescent dye. Alizarin complexone stains mineralized areas of bone by binding to calcium crystals. Alizarin complexone inhibits the reverse transcriptase activity of RAV-2, HIV-1, and RSV with IC50 values of 3.8 μg/mL, 45 μg/mL, and 100 μg/mL, respectively. Alizarin complexone exhibits antiviral activity against HIV-1 and RSV. Alizarin complexone delays RSV-induced tumor induction in chickens.
    ALizarin complexone dihydrate
  • HY-105489
    UC-84
    		Inhibitor
    UC-84 (NSC-615985) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) with anti-HIV activity.
    UC-84
  • HY-106918
    Tivirapine
    		Inhibitor
    Tivirapine (R86183) is a nonnucleoside HIV-1 RT inhibitor against HIV-1-induced cytopathic effects with an EC50 value of 4 nM. Tivirapine inhibits the Yl8lC mutant of HIV-1 RT.
    Tivirapine
  • HY-10572A
    (R)-Efavirenz
    		Inhibitor
    (R)-Efavirenz ((R)-DMP 266) is a non-nucleoside reverse transcriptase inhibitor that acts by non-competitive inhibition of the viral enzyme. (R)-Efavirenz can be metabolized by CYP2B6 to 8-hydroxyefavirenz in a highly stereoselective manner. (R)-Efavirenz is promising to be a useful probe for the CYP2B6 active site and catalytic mechanisms.
    (R)-Efavirenz
  • HY-125810
    4'-Ethynyl-2'-deoxyadenosine
    		Inhibitor
    4'-Ethynyl-2'-deoxyadenosine (4'-E-dA), a nucleoside reverse transcriptase (RT) inhibitor, is an antiretroviral agent which is potent against drug-resistant HIV variants, with an EC50 of 98 nM in MT-4 cells for anti-HIV-1 activity. 4'-Ethynyl-2'-deoxyadenosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    4'-Ethynyl-2'-deoxyadenosine
  • HY-B1826S2
    Adefovir-d4
    		Inhibitor 98.69%
    Adefovir-d4 is the deuterium labeled Adefovir. Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses.
    Adefovir-d<sub>4</sub>
  • HY-105491
    UC-38
    		Inhibitor
    UC-38 (NSC-629243) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) with anti-HIV activity.
    UC-38
  • HY-136972A
    GB-1a
    		Inhibitor
    GB-1a (Biflavanone GB-1a) is a biflavanone HIV-1 reverse transcriptase inhibitor (IC50=236 μM), with an EC50 of 38.0 μM for HIV-1 replication. GB-1a can block the conversion of HIV-1 genomic RNA to DNA and can be used in research related to AIDS (HIV-1 infection). GB-1a can be naturally extracted from the heartwood of Garcinia multiflora Champ.
    GB-1a
  • HY-172996
    NNRT-IN-8
    		Inhibitor
    NNRT-IN-8 (compound 9K) is a potent non-nucleoside reverse transcriptase inhibitor with EC50 values of 0.0014, 0.0041, 0.0077 µM for WT HIV-1, K103N, E138K, respectively.
    NNRT-IN-8
  • HY-173427
    K-5a2
    		Inhibitor
    K-5a2 is the non-isotopic form of ZK-316 (HY-173427S). ZK-316 is a potent and broad-spectrum NNRTI inhibitor with an EC50 value ranging from 0.99 to 75.1 nM. ZK-316 can be used in the study of HIV.
    K-5a2
  • HY-106872
    R82913
    		Inhibitor
    R82913 (9-Cl-TIBO) is a potent and high selective inhibitor of HIV-1 reverse transcriptase with antiviral activity on both an RNA template (negative strand synthesis) and a DNA template (positive strand synthesis). R82913 inhibits the replication of different strains of HIV-I in CEM cells with a median IC50 value of of 0.15 μM.
    R82913
  • HY-105097
    Atevirdine mesylate
    		Inhibitor
    Atevirdine (U 87201E) mesylate is a nonnucleoside reverse transcriptase (NNRT) inhibitor. Atevirdine mesylate can inhibit human immunodeficiency virus type 1 (HIV-1) with an IC50 of 0.06-1.6 μM. Atevirdine mesylate shows highly synergistic effects against Zidovudine/Didanosine-resistant clinical isolates of HIV-1 companied with Zidovudine (HY-17413)/Didanosine (Hy-B0249). Atevirdine mesylate can be used for the research of AIDS.
    Atevirdine mesylate
  • HY-129667
    BM 21.1298
    		Inhibitor
    BM 21.1298 is a selective and high specific nonnucleoside immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) inhibitor with antiviral activity.
    BM 21.1298
  • HY-14920
    Dexelvucitabine
    		Inhibitor 99.52%
    Dexelvucitabine (Reverset; d-d4FC), a Cytidine (HY-B0158) analog, is an orally active nucleoside reverse transcriptase inhibitor. Dexelvucitabine is a powerful agent against HIV-1-resistant viruses containing a thymidine analog and/or M184V mutation in the viral polymerase. Dexelvucitabine is a 2′-Deoxycytidine antiretroviral agent.
    Dexelvucitabine
  • HY-19162
    Thiazolobenzimidazole
    		Inhibitor
    Thiazolobenzimidazole (NSC-625487) is a highly potent nonnucleoside HIV-1 reverse transcriptase inhibitor. Thiazolobenzimidazole inhibits HIV-induced cell killing and viral replication in a variety of human cell lines.
    Thiazolobenzimidazole
  • HY-109056A
    Elsulfavirine sodium
    		Inhibitor
    Elsulfavirine sodium (R-1206) is an orally active human carbonic anhydrase (carbonic anhydrase, CA) inhibitor and an allosteric inhibitor of HIV-1 non-nucleoside reverse transcriptase (NNRT). Elsulfavirine sodium also targets and blocks the interaction between adenylosuccinate lyase (ADSL) and insulin-induced gene proteins INSIG1/2, blocks SREBP-1-mediated de novo lipid synthesis, and inhibits the proliferation of liver cancer cells. The combination of Elsulfavirine sodium and Lenvatinib (HY-10981) produces a synergistic anti-tumor effect. Elsulfavirine sodium is converted into the active metabolite VM1500A in vivo, blocks the DNA polymerase activity of reverse transcriptase, and inhibits HIV-1 replication. Elsulfavirine sodium exhibits a Ki of 1960 nM-52400 nM against human carbonic anhydrase isoforms including I, VII, VI, VA, VB, IX, XIII, XIV. Elsulfavirine sodium is used in studies related to HIV-1 infection and liver cancer.
    Elsulfavirine sodium
  • HY-B0249S
    Didanosine-d2
    		Inhibitor
    Didanosine-d2 is the deuterium labeled Didanosine. Didanosine (Videx) is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.
    Didanosine-d<sub>2</sub>
  • HY-178923
    NNRT-IN-14
    		Inhibitor
    NNRT-IN-14 is an HIV-1 reverse transcriptase inhibitor (IC50 = 0.175 µM). NNRT-IN-14 can form hydrogen bonds with LYS101, PRO225, and PHE227, and π–π stacking with TYR181 and TRP229. NNRT-IN-14 can be used for the study of HIV.
    NNRT-IN-14
  • HY-126082
    (+)-Carbovir triphosphate
    		Inhibitor
    (+)-Carbovir triphosphate is an enantiomer of Carbovir triphosphate (HY-131607). (+)-Carbovir triphosphate is an inhibitor and substrate of HIV reverse transcriptase.
    (+)-Carbovir triphosphate